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Microsomal epoxide hydrolase
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Microsomal epoxide hydrolase : ウィキペディア英語版
Microsomal epoxide hydrolase

In enzymology, a microsomal epoxide hydrolase () is an enzyme that catalyzes the chemical reaction
:cis-stilbene oxide + H2O \rightleftharpoons (+)-(1R,2R)-1,2-diphenylethane-1,2-diol
Thus, the two substrates of this enzyme are cis-stilbene oxide and H2O, whereas its product is (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.
This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is cis-stilbene-oxide hydrolase. Other names in common use include epoxide hydratase (ambiguous), microsomal epoxide hydratase (ambiguous), epoxide hydrase, microsomal epoxide hydrase, arene-oxide hydratase (ambiguous), benzo()pyrene-4,5-oxide hydratase, benzo(a)pyrene-4,5-epoxide hydratase, aryl epoxide hydrase (ambiguous), cis-epoxide hydrolase, and mEH. This enzyme participates in metabolism of xenobiotics by cytochrome p450.
It should also be noted that this class of enzymes plays a role in the uptake of bile salts within the large intestine. It functions as a Na+ dependent transporter.
==References==

* Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 7, Academic Press, New York, 1972, p. 199-212.
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抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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